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Discard unused or expired controlled substances like hydrocodone and acetaminophen Vicodin, Lotab, Norco or oxycodone Oxycontin as soon as possible due to the risk for overdose, theft, or diversion of the medication. Depending on the dosage form, stress testing may include short-term exposure to extremes of heat, light, oxidation, and humidity. Is a medicine still safe to take after its expiration date? It is usually expressed by month and year. This includes moving a medication to a different container, which is the normal practice for pharmacies dispensing prescriptions. Pharmaceutical Compounding—Nonsterile Preparations.

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Beyond-Use and Expiration Date Differences

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These are the manufacturing and testing specifications, which includes upper and lower limits for the amount of the Active Pharmaceutical Ingredient API in each dose unit e.

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U.S. Food and Drug Administration

Thus, moisture or oxygen permeation through a 4 oz bottle is more critical than through a 16 oz bottle of similar construction. The date does not necessarily mean that the drug was found to be unstable after a longer period; it only means that real-time data or extrapolations from accelerated degradation studies indicate that the drug in the closed container will still be stable at that date. Stability profiles of drug products extended beyond labeled expiration dates. In this case, the potential benefit of saving a life is greater than the potential risk of death by not using it all.

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